Ruixuan Gao

This study investigates how cross-linker length affects the mechanical and photodegradation properties of hydrogels used in VIPS for tissue imaging.

This paper introduces a method combining immunohistochemistry with gel-assisted mass spectrometry imaging to enable single-cell lipidomics in complex tissues, revealing disease-specific lipid changes in a neurodegenerative disorder.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

The paper develops a super-resolved 3D spatial transcriptomics method to study cell-type and brain-region-specific changes in Mettl3 expression after adolescent alcohol exposure in rats.

The paper develops photochemical sectioning to enable nanoscale volumetric imaging of whole-mount specimens, demonstrating its application in analyzing axon degeneration and myelination in mouse olfactory bulbs.

The paper identifies a neural correlate of individual odor preference in Drosophila by linking microscale variations in the ORN-PN synapse to idiosyncratic behavior.

The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.

The paper visualizes dense distributions of immunolabeled proteins in adult macaque visual cortex using expansion microscopy and light sheet imaging, enabling multimodal atlas creation.

The paper develops a method to rapidly reconstruct neural circuits with single synapse resolution using tissue expansion and lattice light sheet microscopy, validated in Drosophila.

This paper introduces Cal-ID, a tool that records calcium signaling and neuronal activity by biotinylating nearby proteins, enabling high-resolution molecular mapping.

The paper develops cell body-targeted calcium indicators to improve signal fidelity in one-photon imaging of neural activity in live mice and zebrafish.

The paper combines expansion and lattice light sheet microscopy to enable high-speed, nanoscale molecular imaging of neural circuits across large volumes.

This paper introduces Light Sheet Theta Microscopy (LSTM) for high-resolution quantitative imaging of large biological systems, showing it achieves superior uniform resolution compared to traditional Light Sheet Microscopy.