Swetha Gowrishankar

The paper identifies lysosomal heterogeneity in microglia and shows that AP-4 regulates compartment-specific differences in protease content and CD68 distribution.

The paper compares clinical and behavioral effects of different MAPK8IP3 variants in humans and mice, showing shared and distinct phenotypes linked to specific protein domains.

The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.

A small molecule modulates neuronal lysosome positioning and function, reducing amyloid-beta levels and rescuing pathologies in human neurons and zebrafish.

The paper shows that ATG9A forms distinct vesicle phases from synaptic vesicle proteins within synapsin condensates in fibroblasts and nerve terminals.