Günter P. Wagner

Conceptus attachment coincides with initiation of an anti-inflammatory cytokine profile in the pig endometrium

The paper investigates the transition from pro- to anti-inflammatory states in the pig endometrium during blastocyst attachment, identifying key genes and cell types involved in inflammation resolution.

Precocial ancestry of placental mammals

The paper reconstructs the evolutionary history of neonatal maturity in mammals and finds that the eutherian ancestor likely gave birth to precocial neonates, challenging the idea that precociality evolved multiple times within eutherians.

Identifying genes underlying parallel evolution of stromal resistance to placental and cancer invasion

The paper identifies genes associated with stromal resistance to placental and cancer invasion by comparing species and analyzing fibroblast responses.

Fetal inflammatory signals regulate maternal investment in a pregnant marsupial

The paper investigates how fetal inflammatory signals in marsupials influence maternal investment, finding that IL-1 and IL-6 inhibition increases fetal biomass but reduces litter survival.

Pseudo-perplexity in One Fell Swoop for Protein Fitness Estimation

The paper introduces a method to estimate protein fitness using pseudo-perplexity from a single forward pass through a language model, achieving state-of-the-art results on a benchmark.

Comparative single cell analysis reveals complex patterns of cell type and cell signaling innovations at the fetal-maternal interface

This paper compares single-cell data across six mammalian species to uncover evolutionary patterns in cell types and signaling at the fetal-maternal interface, finding conserved gene signatures and stepwise evolution of decidual cells.

Genetic Characterization of the Cell Types of in Developing Feathers, and the Evolution of Feather Complexity

The paper characterizes feather cell types in developing chicken embryos using single-cell RNA sequencing and identifies a new cell type, while analyzing their evolutionary relationships.

High fitness paths can connect proteins with low sequence overlap

This paper develops an algorithm to generate viable sequence paths between distantly related proteins, using ESM2 to evaluate fitness and maintain high viability through single residue changes.

Hallmarks of uterine receptivity predate placental mammals

This paper compares single-cell transcriptomes of uterine and embryonic tissues across rodents and opossums to show that marsupial uteri activate an ancestral signaling axis similar to eutherian implantation, but with inhibitory signals preventing invasion.

Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossum

The paper compares spermatogenic gene expression in opossum and mouse to identify evolutionary dynamics in germline biology.

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

This study identifies a SNP that affects Wnt4 expression in endometrial stroma, linking it to pregnancy, endometriosis, and reproductive cancers through differential gene regulation.

Proteotype Co-evolution and Diversity in Mammals

The paper quantifies proteomic and phosphoproteomic layers in mammalian fibroblasts to show transcriptome-proteome co-evolution and variability control across species.

Single-cell analysis of prostaglandin E2-induced decidual cell differentiation: does extracellular 8-Br-cAMP cause artifacts?

This study compares PGE2 and cAMP-based protocols for inducing decidualization in human endometrial stromal fibroblasts, finding that PGE2 induces a more physiologically relevant transcriptomic response.

Subdivision of ancestral scale genetic program underlies origin of feathers and avian scutate scales

The paper investigates the evolutionary origin of feathers and avian scales by comparing transcriptomes from chicken, emu, and alligator skin appendages, revealing shared gene expression patterns between feathers and scutate scales.

The Core Transcriptome Of Mammalian Placentas And The Divergence Of Expression With Placental Shape

The paper identifies 115 core genes expressed in all eutherian placentas and finds genes associated with placental shape and pre-eclampsia.