Olivier Silvie

A structure-based epitope tagging approach identifies vulnerable sites on the malarial P36-P52 protein complex for antibody-mediated neutralization of Plasmodium sporozoites

The paper identifies vulnerable sites on the P36-P52 protein complex of Plasmodium sporozoites using structural biology and functional assays, showing that antibodies targeting these sites can neutralize SPZ invasion.

The CLAMP-Linked Invasion Protein (CLIP) plays an essential role in Plasmodium berghei zoites

This study shows that CLIP is essential for host cell invasion by both merozoites and sporozoites of P. berghei, supporting a conserved role of the CLAMP-CLIP-SPATR complex in apicomplexan invasion.

Spatiotemporal analysis of sporozoite maturation and infectivity

This study investigates the spatiotemporal maturation and infectivity of Plasmodium sporozoites across different mosquito stages, showing a gradient of infectivity from midgut to saliva.

Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei

This paper develops a new Plasmodium berghei parasite line with constitutive Cas9 and inducible Cre recombinase for conditional gene editing, demonstrating its use in knocking out the CLAMP gene.

Specialized S-type ribosomes of Plasmodium yoelii enhance host-to-vector malaria transmission

This study shows that S-type ribosomes in Plasmodium yoelii are not essential for mosquito-stage development but promote host-to-vector transmission and have distinct roles in blood-stage development.

Pleiotropic Roles for the Plasmodium berghei RNA Binding Protein UIS12 in Transmission and Oocyst Maturation

This study shows that UIS12 in Plasmodium berghei is essential for gametocyte formation and oocyst development in mosquitoes, leading to life cycle arrest.