Andrey V. Romanyuk

Expanding all-α-helical protein space through rational computational design

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

Biomolecular condensation using de novo designed globular proteins

This paper designs globular proteins that drive biomolecular condensation and demonstrates their use in forming dynamic condensates in cells.

Rapid Assessment of Size, Shape, and Chemical Complementarity of Ligands for Computational Protein Design

The paper develops a computational method to design proteins that bind small molecules tightly and specifically, validated experimentally with X-ray crystallography and functional assays.

Maturation and conformational switching of a de novo designed phase-separating polypeptide

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

Assembling membraneless organelles from de novo designed proteins

The paper designs genetically encoded polypeptides that form membraneless organelles in E. coli and use them to co-compartmentalise a functional enzyme pair.