Jennifer J. McManus

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This paper designs globular proteins that drive biomolecular condensation and demonstrates their use in forming dynamic condensates in cells.

The paper develops a computational method to design proteins that bind small molecules tightly and specifically, validated experimentally with X-ray crystallography and functional assays.

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

The paper designs genetically encoded polypeptides that form membraneless organelles in E. coli and use them to co-compartmentalise a functional enzyme pair.