Author

Julia Konovalova

University of HelsinkiORCID 0000-0002-0534-8028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrii DomanskyiiD· 3 shared Kelvin C. LukiD· 2 shared Mikko AiravaaraiD· 2 shared Piotr ChmielarziD· 2 shared Şafak EriD· 2 shared Anne E. PanhelaineniD· 1 shared Annika SorvariiD· 1 shared Anthony Robert WhiteiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Andrii DomanskyiORCID

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3 papers

Recent·Most cited

PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and D

Julia Konovalova, Şafak Er, Justyna Barut, Katarzyna Rafa–Zabłocka, Kelvin C. Luk, Małgorzata Figiel, Mikko Airavaara, Andrii Domanskyi, Piotr Chmielarz

The paper shows that PKB/AKT activation protects dopamine neurons from ER stress and -syn aggregation via Cathepsins B and D, suggesting a potential gene therapy approach for Parkinson's disease.

bioRxiv · Sep 23, 2022 · PreprintNeuroscience

Alzheimer's disease alters astrocytic functions related to neuronal support andtranscellular internalization of mitochondria

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid A. Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, , Katja M. Kanninen

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

bioRxiv · Sep 15, 2021 · PreprintNeuroscience

GDNF/RET signaling pathway activation eliminates Lewy Body pathology in midbrain dopamine neurons

Piotr Chmielarz, Şafak Er, Julia Konovalova, Laura Bandrés, Irena Hlushchuk, Katrina Albert, Anne E. Panhelainen, Kelvin C. Luk, Mikko Airavaara, Andrii Domanskyi

This study shows that activating the GDNF/RET signaling pathway prevents Lewy Body pathology in dopamine neurons by blocking α-synuclein aggregation.

Movement Disorders · Sep 16, 2020Peer-reviewedNeuroscience