Author

Marja Koskuvi

University of HelsinkiORCID 0000-0002-1646-9992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

Jari KoıstınahoiD· 8 shared Šárka LehtoneniD· 6 shared Jari TiihoneniD· 5 shared Ilkka Ojansuu· 4 shared Olli VaurioiD· 4 shared Markku LähteenvuoiD· 3 shared Tarja MalmiD· 3 shared Anastasia ShakirzyanovaiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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8 shared papersNeuroscience

Jari KoıstınahoORCID

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8 papers

Recent·Most cited

A schizophrenia-associated radial glia cell state perturbs early human brain development

Susmita Malwade, Samudyata Samudyata, Jessica Gracias Lekander, Angelika Langeder, Katharina Weinberger, Marja Koskuvi, Ana Osório Oliveira, Šárka Lehtonen, Luis Enrique Arroyo‐García, Aiden Peter Corvin, Sarah E. Bergen, Ilkka Ojansuu, Olli Vaurio, Jari Koıstınaho, Jari Tiihonen, Carl M. Sellgren

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience

Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage

Nadine Huber, Tomi Hietanen, Sami Heikkinen, Anastasia Shakirzyanova, Dorit B. Hoffmann, Hannah Rostalski, Ashutosh Dhingra, Salvador Rodrı́guez-Nieto, Sari Kärkkäinen, Marja Koskuvi, Eila Korhonen, Päivi H. Hartikainen, Katri Pylkäs, Johanna Krüger, Tarja Malm, , Annakaisa Haapasalo

This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.

Molecular Psychiatry · Sep 26, 2025Peer-reviewedNeuroscience

Astrocytes regulate neuronal network burst frequency through NMDA receptors species- anddonor-specifically

Noora Räsänen, Jari Tiihonen, Marja Koskuvi, Šárka Lehtonen, Nelli Jalkanen, Nelli Karmila, Isabelle Weert, Olli Vaurio, Ilkka Ojansuu, Markku Lähteenvuo, Olli P. H. Pietiläinen, Jari Koıstınaho

The paper shows human astrocytes influence neuronal network burst frequency via NMDA receptors, with differences between human and rat astrocytes and effects in schizophrenia-related cells.

bioRxiv · Dec 9, 2023 · PreprintNeuroscience

Kynurenic acid promotes activity-dependent synaptic pruning in schizophrenia

Funda Orhan, Susmita Malwade, Neda Khanlarkhani, Asimenia Gkoga, Oscar Jungholm, Marja Koskuvi, Šárka Lehtonen, Lilly Schwieler, Kent E. Jardemark, Jari Tiihonen, Jari Koıstınaho, Sophie Erhardt, Göran Engberg, Samudyata Samudyata, Carl M. Sellgren

This study shows that kynurenic acid promotes microglia-mediated synaptic pruning in schizophrenia by reducing neuronal activity and linking genetic risk variants to KYNA production.

bioRxiv · Oct 19, 2023 · PreprintNeuroscience

Alzheimer's disease alters astrocytic functions related to neuronal support andtranscellular internalization of mitochondria

Riikka Lampinen, Irina Belaya, Liudmila Saveleva, Jeffrey R. Liddell, Dzhessi Rait, Mikko T. Huuskonen, Raisa Giniatullina, Annika Sorvari, Liisi Soppela, Nikita Mikhailov, Isabella Boccuni, Rashid A. Giniatullin, Marcela Cruz-Haces, Julia Konovalova, Marja Koskuvi, , Katja M. Kanninen

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

bioRxiv · Sep 15, 2021 · PreprintNeuroscience

Molecular signaling pathways underlying schizophrenia

Jari Tiihonen, Marja Koskuvi, Markku Lähteenvuo, Kalevi Trontti, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko K Lönnqvist, Sebastian Therman, Jaana Suvisaari, Lesley Cheng, Antti J. Tanskanen, Heidi T. Taipale, Šárka Lehtonen, Jari Koıstınaho

The paper identifies molecular pathways and potential treatments for schizophrenia using stem cell-derived neurons and pharmacological associations.

Schizophrenia Research · May 15, 2021Peer-reviewedNeuroscience

Microglia orchestrate neuronal activity in brain organoids

Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez‐Budia, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto, Damián Hernández, Alice Pébay, Jari Koıstınaho, Šárka Lehtonen, Paula Korhonen, Tarja Malm

This study shows that incorporating microglial progenitors into human brain organoids supports neuronal maturation and synaptic activity.

bioRxiv · Dec 8, 2020 · PreprintNeuroscience

Patient iPSC-astrocytes show transcriptional and functional dysregulation in schizophrenia

Marja Koskuvi, Šárka Lehtonen, Kalevi Trontti, Meike Hedwig Keuters, Ying Chieh Wu, Hennariikka Koivisto, Anastasia Ludwig, L. M. Plotnikova, Pekka L. J. Virtanen, Noora Räsänen, Satu Kaipainen, Ida Hyötyläinen, Hiramani Dhungana, Raisa Giniatullina, Ilkka Ojansuu, , Jari Koıstınaho

The paper shows that astrocytes from schizophrenia patients exhibit transcriptional and functional changes, including inflammation and synaptic pathway alterations, which are partially reversible with clozapine treatment.

bioRxiv · Oct 23, 2020 · PreprintNeuroscience