Christopher L. Sansam

The paper shows that cells compensate for reduced replication origin firing by accelerating replication fork progression through a CDK1-RIF1 mechanism.

The paper identifies how CDK activity regulates TRESLIN and MTBP to activate dormant replication origins, enhancing genome duplication under CDK-hyperactive conditions.

The paper investigates TICRR/TRESLIN and MTBP chromatin binding in human cells, showing G1-specific dependency on TRESLIN and independence from licensed origins.

This study shows that DUE-B is not essential for zebrafish development or DNA replication, suggesting it has redundant or specialized roles in vertebrates.