Gheorghe Chistol

The paper shows that TOPBP1-dependent DNA damage processing leads to CENP-A loss and centromere destabilization in inviable Xenopus hybrids.

This study uses single-molecule imaging to show that Pol δ and Pol are not stably tethered to the eukaryotic replisome, revealing distributive lagging strand synthesis.

This study identifies Mcm10 and RecQL4 as key proteins that activate the eukaryotic replicative DNA helicase CMG through a coordinated mechanism.

This study shows that DUE-B is not essential for zebrafish development or DNA replication, suggesting it has redundant or specialized roles in vertebrates.

The paper uses single-molecule imaging to reveal how two CMG helicases are assembled and activated at replication origins in metazoan genomes.

This study shows that single-strand breaks cause replisome disassembly by generating different fork collapse structures depending on the strand, with CMG being passively removed during leading strand collapse and actively unloaded during lagging strand collapse.