Author

Alexa Semon

Children's Hospital of PhiladelphiaORCID 0000-0002-0551-1446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Christopher A. HunteriD· 1 shared Daniel L. AldridgeiD· 1 shared David Michael AronoffiD· 1 shared Emma Elizabeth FurthiD· 1 shared Gavyn Chern Wei BeeiD· 1 shared Joseph P. ZackulariD· 1 shared Joshua Soto OcañaiD· 1 shared Juliana Diamantino· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Christopher A. HunterORCID

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1 paper

Recent·Most cited

Pharmacological reduction of neutrophil infiltration reduces Clostridioides difficile infection severity

Orlaith Keenan, Joshua Soto Ocaña, Alexa Semon, Tao-You Zhou, Kassy Donohoe, Emma Elizabeth Furth, Gavyn Chern Wei Bee, Daniel L. Aldridge, Juliana Diamantino, Christopher A. Hunter, Ken Cadwell, David Michael Aronoff, Joseph P. Zackular

This study shows that misoprostol reduces C. difficile infection severity by decreasing neutrophil infiltration and G-CSF levels, highlighting innate immune modulation as a therapeutic strategy.

mBio · Mar 30, 2026Peer-reviewedImmunology