Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair
Wei Wu, Sarah E. Kargbo-Hill, William J. Nathan, Jacob Paiano, Elsa Callén, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, J Colon, Dali Zong, Raffaella De Pace, Han‐Yu Shih, Steven L. Coon, Maia Parsadanian, Raphael Pavani, , André Nussenzweig
The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.
Nature · Mar 25, 2021Peer-reviewedNeuroscience