Author

Andrés Canela

Kyoto University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

André NussenzweigiD· 1 shared Chongyi CheniD· 1 shared Dali ZongiD· 1 shared Dongpeng WangiD· 1 shared Elsa CalléniD· 1 shared Fumiyoshi IshidateiD· 1 shared Han‐Yu ShihiD· 1 shared Hana HanzlíkováiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

André NussenzweigORCID

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3 papers

Recent·Most cited

Human FACT complex coordinates cohesin and transcription on chromatin

Jonay García-Luis, Andrés Canela, Valeriya Malysheva, Toyoaki Natsume, Mohammad Mahdi Karimi, Masato T. Kanemaki, Mikhail Spivakov, Luís Aragón

This study shows that the FACT complex regulates cohesin dynamics on chromatin, facilitating loop extrusion and preventing cohesin accumulation in transcribed regions.

bioRxiv · Oct 7, 2026 · PreprintBiochemistry

Neuronal migration induces DNA damage in developing brain

Zhejing Zhang, Andrés Canela, Peilin Zou, Takahiro Furuta, Noriko Takeda, Takumi Kawaue, Naotaka Nakazawa, Mai Saeki, Maki Utsunomiya, Junko Kurisu, Fumiyoshi Ishidate, Hiroyuki Sasanuma, Yusuke Kishi, Mineko Kengaku

The paper shows neuronal migration in developing brains causes DNA damage through mechanostress, which is repaired normally but can lead to disease if unresolved.

bioRxiv · Jun 10, 2025 · PreprintCell Biology

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

Wei Wu, Sarah E. Kargbo-Hill, William J. Nathan, Jacob Paiano, Elsa Callén, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, J Colon, Dali Zong, Raffaella De Pace, Han‐Yu Shih, Steven L. Coon, Maia Parsadanian, Raphael Pavani, , André Nussenzweig

The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.

Nature · Mar 25, 2021Peer-reviewedNeuroscience