Jacob Paiano

This study shows that activating the UPR in muscle cells reprograms metabolism from carbohydrate to lipid metabolism through transcriptional changes.

The paper shows DNA-PK promotes DNA end resection in G0 cells but not in G1 or G2 phase cells, revealing a cell cycle-specific role in DSB repair.

The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.

This study identifies ZCWPW1 as a dual histone methylation reader essential for meiotic DSB repair in vertebrates, showing its co-expression and co-evolution with PRDM9.

This study directly detects meiotic DSBs and resection in vertebrates using END-seq on mouse spermatocytes, identifying a novel recombination intermediate regulated by ATM and PRDM9.