Elsa Callén

ARP2/3- and resection-coupled genome reorganization facilitates translocations

The paper shows that ARP2/3-dependent nuclear actin polymerization and DNA end-resection coordinate genome reorganization to facilitate homology-directed repair and prevent translocations.

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

This study identifies RIF1 as a phosphopeptide-binding protein that interacts with phosphorylated 53BP1 epitopes to facilitate DNA repair and modulate shieldin recruitment.

The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice

This study identifies a transcriptional network involving THAP1 that regulates SHLD1 expression, affecting DNA repair choice and linking DNA damage to dystonia.

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.

ATM and PRDM9 Regulate SPO11-bound Recombination Intermediates During Meiosis

This study directly detects meiotic DSBs and resection in vertebrates using END-seq on mouse spermatocytes, identifying a novel recombination intermediate regulated by ATM and PRDM9.