Author
National Institutes of HealthORCID 0000-0002-7187-2995Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Geylani Can, Maksym Shyian, Archana Krishnamoorthy, Samreen Ahmed, Yang Lim, Alex Wu, Raphael Pavani, Manal S. Zaher, André Nussenzweig, Markus Räschle, Thomas E. Wilson, Thomas W. Glover, Johannes C. Walter, David S. Pellman
The paper identifies a phospho-switch mechanism that reprograms TRAIP to ubiquitylate replisomes in mitosis, enabling disassembly of unreplicated DNA.
Science · Jul 2, 2026Peer-reviewedBiochemistry
Benura Azeroglu, Wei Wu, Raphael Pavani, Ranjodh Singh Sandhu, Tadahiko Matsumoto, André Nussenzweig, Eros Lazzerini Denchi
The paper uses END-seq to analyze telomere sequences in ALT-positive cancer cells, revealing conserved and unique features of terminal telomeric sequences.
eLife · Aug 1, 2025Peer-reviewedMolecular Biology
Bert van de Kooij, A. Schreuder, Raphael Pavani, Veronica Garzero, Arne van Hoeck, Marta San Martín Alonso, Dana Koerse, Tiemen J. Wendel, E. Callen, J. Boom, Hailiang Mei, Edwin P. J. G. Cuppen, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer
This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.
bioRxiv · Feb 24, 2023 · PreprintMolecular Biology
Faith C. Fowler, Bo-Ruei Chen, Nicholas Zolnerowich, Wei Wu, Raphael Pavani, Jacob Paiano, Chelsea Peart, Zulong Chen, André Nussenzweig, Barry P. Sleckman, Jessica K. Tyler
The paper shows DNA-PK promotes DNA end resection in G0 cells but not in G1 or G2 phase cells, revealing a cell cycle-specific role in DSB repair.
eLife · May 9, 2022Peer-reviewedMolecular Biology
Gabriel E. Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi, Natasha C. Koussa, Raphael Pavani, William J. Nathan, Frida Belinky, Ashraf Mohammed, Марек Напиерала, Karen Usdin, Aseem Z. Ansari, Sergei M. Mirkin, André Nussenzweig
The paper identifies dynamic DNA secondary structures in vivo that contribute to genome instability by analyzing ssDNA converted to DSBs using S1-END-seq.
bioRxiv · Jan 19, 2022 · PreprintMolecular Biology
Wei Wu, Sarah E. Kargbo-Hill, William J. Nathan, Jacob Paiano, Elsa Callén, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, J Colon, Dali Zong, Raffaella De Pace, Han‐Yu Shih, Steven L. Coon, Maia Parsadanian, Raphael Pavani, , André Nussenzweig
The paper identifies DNA single-strand breaks (SSBs) accumulating at neuronal enhancers and shows their repair involves PARP1, XRCC1, and DNA polymerase β.
Nature · Mar 25, 2021Peer-reviewedNeuroscience