Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation
Francesca Bonato, Rebeca París-Ogáyar, Ahmed Soliman, Óscar Fernández, Beatriz Álvarez‐Bernad, Juan Francisco Giménez-Abián, Daniel Lucena‐Agell, Rafael Hortigüela, Lisha Singh, Juan Estévez‐Gallego, Wei‐Shuo Fang, Denisa Ondruskova, Valle Palomo, Federico Gago, Marcus Braun, , María A. Oliva
The paper designs and characterizes PTX analogues to separate MT stabilization from structural changes, showing that compound 1b preserves native MT structure and physiological Tau dynamics.
Journal of Medicinal Chemistry · Jul 30, 2026Peer-reviewedMolecular Biology