Thomas Rattei

A cell death screen identifies macrophage-depleting agents with therapeutic potential

This study identifies three small molecule inhibitors that reduce macrophage survival and viability, showing therapeutic potential in models of inflammation and cancer.

Pro- and anti-inflammatory macrophages adjust UCP2 protein levels based on their intrinsic metabolism and available metabolites

This study shows that pro- and anti-inflammatory macrophages adjust UCP2 levels based on metabolism and metabolites, with pyruvate and hypoxia playing key roles.

Kineochelins - a novel group of siderophores from an Antarctic bacterium

This paper characterizes kineochelins, novel siderophores from an Antarctic actinomycete, showing their iron-chelating activity and ecological relevance.

Screening great ape museum specimens for DNA viruses

The paper screens great ape museum specimens for DNA viruses, identifying multiple viruses and obtaining near-complete genomes, including high-coverage hepatitis B virus genomes.

Expanding the cultivated human archaeome by targeted isolation of novel Methanobrevibacter strains from fecal samples

This study isolates and characterizes novel Methanobrevibacter strains from human fecal samples, expanding the cultivated archaeome and linking them to gastrointestinal health.

Maximizing Efficiency in SedaDNA Analysis: A Novel Extract Pooling Approach

This paper introduces a pooled testing method for sedimentary DNA analysis, reducing costs and lab time by up to 70% while maintaining aDNA signal detection.

One to host them all: genomics of the diverse bacterial endosymbionts of the spider Oedothorax gibbosus

The paper analyzes bacterial endosymbionts in spiders, reconstructing their genomes and showing their evolutionary relationships and interactions with the host.

Critical Assessment of Metagenome Interpretation - a benchmark of computational metagenomics software

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.