Paul Ettel

This study identifies an arginine-dependent metabolic mechanism by which alternatively polarized neutrophils restrain macrophage-driven inflammation in mouse models and human diseases.

This study identifies three small molecule inhibitors that reduce macrophage survival and viability, showing therapeutic potential in models of inflammation and cancer.

This study uses PET and multi-OMICS to show stress activates brown adipose tissue and alters brain metabolism in mice, identifying metabolic hubs and signatures relevant to mental health and disease models.

This study identifies IRF4 as a master regulator of multinucleated giant cell formation through integrated single-cell and bulk RNA sequencing, CRISPR/Cas9 editing, and in vivo fate mapping.