Thomas Weichhart

Alternatively polarized neutrophils metabolically restrain macrophage-driven inflammation

This study identifies an arginine-dependent metabolic mechanism by which alternatively polarized neutrophils restrain macrophage-driven inflammation in mouse models and human diseases.

A cell death screen identifies macrophage-depleting agents with therapeutic potential

This study identifies three small molecule inhibitors that reduce macrophage survival and viability, showing therapeutic potential in models of inflammation and cancer.

Stress-induced Metabolic Remodeling of Adipose and Brain Tissue Revealed by Positron Emission Tomography

This study uses PET and multi-OMICS to show stress activates brown adipose tissue and alters brain metabolism in mice, identifying metabolic hubs and signatures relevant to mental health and disease models.

Pro- and anti-inflammatory macrophages adjust UCP2 protein levels based on their intrinsic metabolism and available metabolites

This study shows that pro- and anti-inflammatory macrophages adjust UCP2 levels based on metabolism and metabolites, with pyruvate and hypoxia playing key roles.

Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models

This study uses advanced human co-culture models to show that fibroblast-derived thrombospondin-1 drives macrophage metabolic remodeling and polarization in tumor environments.

IRF4 is a master regulator of multinucleated giant cell formation

This study identifies IRF4 as a master regulator of multinucleated giant cell formation through integrated single-cell and bulk RNA sequencing, CRISPR/Cas9 editing, and in vivo fate mapping.

Itaconate is metabolized to 2-hydroxymethylsuccinate through a CoA-independent degradation pathway in mitochondria

The paper identifies 2-hydroxymethylsuccinate as a product of itaconate metabolism via a CoA-independent pathway and shows tissue-specific degradation routes.

Proteomic and Metabolomic Profiling of Archaeal Extracellular Vesicles from the Human Gut

This study profiles proteomic and metabolomic features of archaeal extracellular vesicles from the human gut, revealing their structural similarity to bacterial EVs and their potential to modulate immune responses.

Computational metabolic modeling unveils gut microbiomes role in metabolic shifts during murine cancer cachexia

This study identifies cachexia-associated microbial metabolites using computational modeling and metabolomic analyses in a murine cancer model.

24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

This study shows that NorUDCA modulates CD8+ T cell metabolism and function, reducing hepatic inflammation in a mouse model of immune-mediated liver disease.