Tue Sparholt Jørgensen

Human infection with an ape Plasmodium vivax-like parasite

The paper reports a case of human infection with an ape-like Plasmodium vivax parasite, identified through whole-genome sequencing, suggesting zoonotic transmission from wild gorillas and chimpanzees.

A long-hidden prevalent PCR artifact and its application in DNA library screening

The paper identifies a new PCR artifact called 'PCR leaping' and develops a DNA library screening method using it for natural product discovery.

Tying up loose ends: Recovering thousands of missing telomeres from Streptomyces and other Streptomycetaceae genomes

The paper develops Telomore to recover missing telomeres in Streptomycetaceae genomes, increasing detection from 0% to 37% and identifying a new telomere-related protein family.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

Pangenome mining of the Streptomyces genus redefines their biosynthetic potential

The paper analyzes 2,371 Streptomyces genomes to refine biosynthetic gene cluster (BGC) diversity using MASH-clusters and reveals conserved genomic structures suggesting vertical inheritance.

Critical Assessment of Metagenome Interpretation - the second round of challenges

The paper evaluates metagenomic software tools using realistic datasets, highlighting improvements in assembly and taxon profiling while identifying remaining challenges in virus/archaea detection and reproducibility.

CRISPR-BEST: a highly efficient DSB-free base editor for filamentous actinomycetes

The paper develops CRISPR-BEST, a DSB-free base editing system for filamentous actinomycetes, achieving single-nucleotide resolution in Streptomyces species.

The whole genome sequence and mRNA transcriptome of the tropical cyclopoid copepod Apocyclops royi

This paper presents the first whole genome sequence and mRNA transcriptome of the copepod Apocyclops royi, providing genomic resources for further study.

The genome and mRNA transcriptome of the cosmopolitan calanoid copepod Acartia tonsa Dana improve the understanding of copepod genome size evolution

The paper reports the first genome and transcriptome of Acartia tonsa, revealing a 14-fold genome size difference among copepods and expanding genetic resources for evolutionary studies.

Critical Assessment of Metagenome Interpretation - a benchmark of computational metagenomics software

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.

Plasmids, Viruses, And Other Circular Elements In Rat Gut

The paper analyzes circular DNA elements in rat gut microbiomes from two environments, finding differences in element size and antibiotic resistance gene diversity linked to human impact.