Dana W.Y. Tsui

Study Design and Interim Analysis of the Cancer Lifetime Assessment Screening Study in Canines (CLASSiC): The First Prospective Cancer Screening Study in Dogs Using Next-Generation Sequencing-Based Liquid Biopsy

The paper presents an interim analysis of a canine cancer screening study using NGS-based liquid biopsy, showing increased preclinical cancer detection with OncoK9(R) testing.

Next-generation sequencing-based liquid biopsy can be used for detection of residual disease and cancer recurrence monitoring in dogs

This study evaluates a next-generation sequencing-based liquid biopsy test for detecting residual disease and monitoring cancer recurrence in dogs, finding it can identify recurrence earlier than clinical assessment.

A large-scale retrospective study in metastatic breast cancer patients using circulating tumor DNA and machine learning to predict treatment outcome and progression-free survival

This study uses ctDNA from metastatic breast cancer patients and a Bayesian model to predict treatment response and progression-free survival, outperforming alternative methods.

Blood-based liquid biopsy for comprehensive cancer genomic profiling using next-generation sequencing: an emerging paradigm for noninvasive cancer detection and management in dogs

This study shows that blood-based liquid biopsy using next-generation sequencing can detect genomic alterations in dogs with cancer, matching tumor tissue findings and identifying alterations from spatially separated tumor sites.

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.