Dashi Qi

The paper shows that enhanced ERK signaling in human cortical radial glia drives cortical neuron expansion through interactions with PKA signaling and cell cycle regulation.

This study challenges the belief that lateral/caudal ganglionic eminence contributes significantly to cortical oligodendrocyte progenitor cells, showing instead that its contribution is minimal.

The paper uses transcriptomic profiling and machine learning to identify 277 transcription factor networks involved in striatal neuron survival and their link to Huntington's disease.