Inflammatory IL-1 signaling remodels epidermal stem cell compartments by suppressing Wnt activity
Hung Manh Phung, Ikuto Nishikawa, Nguyen Thi Kim Nguyen, Aiya K. Yesbolatova, Ahmed M. Hegazy, Tomson Kosasih, Jun Aoi, Satoshi Fukushima, Sho Hiroyasu, Hitoshi Takizawa, Aiko Sada
The paper shows that IL-1 signaling suppresses Wnt activity in epidermal stem cells during inflammation, leading to changes in stem cell compartments that can be reversed by Wnt reactivation.
bioRxiv · Feb 9, 2026 · PreprintDevelopmental Biology