Author

Colleen S. Hughes

Montreal Neurological Institute and HospitalORCID 0000-0002-0632-4060Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:imaging· 3 Approach:statistical model· 3 Research Focus:spatial domain detection· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gary R. TurneriD· 2 shared Giulia BaracchiniiD· 2 shared R. Nathan SprengiD· 2 shared Alexander J. LoweiD· 1 shared Alfie R. WearniD· 1 shared Amber W. Lockrow· 1 shared Andrew J. SaykiniD· 1 shared Anne C. KrendliD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Gary R. TurnerORCID

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Author profile →

3 papers

Recent·Most cited

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease

Alfie R. Wearn, Kate M. Onuska, Hayley R. C. Shanks, Rahul Gaurav, Stéphane Lehéricy, Giulia Baracchini, Colleen S. Hughes, Jennifer Tremblay‐Mercier, Sridar Narayanan, John C.S. Breitner, Judes Poirier, Taylor W. Schmitz, Gary R. Turner, R. Nathan Spreng

Alzheimer s & Dementia · Apr 1, 2026Peer-reviewedNeuroscience

Individualized Mapping of Functional Brain Networks in Older Adulthood

Colleen S. Hughes, Anne C. Krendl, Roberto C. French, Shannon L. Risacher, Yu‐Chien Wu, Andrew J. Saykin, Richard F. Betzel

This study shows that individualized functional brain network mapping in older adults reveals more heterogeneity and improves network fidelity compared to group-averaged approaches.

Imaging Neuroscience · Jan 1, 2026Peer-reviewedNeuroscience

Age differences in the functional architecture of the human brain

Roni Setton, Laetitia Mwilambwe-Tshilobo, Manesh Girn, Amber W. Lockrow, Giulia Baracchini, Colleen S. Hughes, Alexander J. Lowe, Benjamin N. Cassidy, Jian Li, Wen‐Ming Luh, Danilo Bzdok, Richard M. Leahy, Tian Ge, Daniel S. Margulies, Bratislav Mišić, , R. Nathan Spreng

This study examines age-related changes in brain functional architecture using multi-scale fMRI analyses in younger and older adults, finding both global and network-specific dedifferentiation patterns.

Cerebral Cortex · Jan 28, 2022Peer-reviewedNeuroscience