Judes Poirier

CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer's disease

The paper investigates the association between CSF complement proteins and early AD pathology in at-risk individuals, finding C1q and Factor H linked to tau and synaptic markers.

Reducing CETP activity prevents memory decline in an Alzheimer's disease mouse model

The paper shows that reducing CETP activity in Alzheimer's disease mice prevents memory decline and alters lipid and gene expression profiles, supporting CETP as a therapeutic target.

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease

Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

Cholinergic synaptic plasticity shapes resilience and vulnerability to tau

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers

The paper examines how precuneus activity during memory retrieval relates to future amyloid burden and cognitive outcomes in APOE4 carriers and non-carriers.

PTPRS is a novel marker for early tau pathology and synaptic integrity in Alzheimer's disease

The paper identifies PTPRS as a neuroprotective marker in Alzheimer's disease, showing associations with reduced tau pathology and synaptic degeneration, particularly in males.

Joint signatures of morphological and microstructural inter-individual variation in the Alzheimer's spectrum

The paper identifies joint signatures of microstructural and morphological changes in the Alzheimer's spectrum using MRI metrics and non-negative matrix factorization, linking them to risk factors and disease progression.

Social isolation is linked to classical risk factors of Alzheimer's disease-related dementias

The paper examines the link between social isolation and Alzheimer's disease-related dementias risk using large population cohorts.

Assessment of white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease

This study assesses white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease by analyzing signal measures from different MRI contrasts and their associations with clinical variables.

APOE ϵ2 vs APOE ϵ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation

The paper examines how APOE ε2 and ε4 variants affect hippocampus-default network subregion co-variation, revealing sex-specific associations with lifestyle and health traits.

Vascular burden is associated with a decline in default-mode and global resting-state functional connectivity in individuals at risk for Alzheimer's disease

This study finds that higher cholesterol and diastolic blood pressure levels are linked to reduced brain functional connectivity over time in individuals at risk for Alzheimer's disease.

Creation of an Open Science Dataset from PREVENT-AD, a Longitudinal Cohort Study of Pre-symptomatic Alzheimer's Disease.

Bundle-specific associations between white matter microstructure and Aβ and tau pathology at their connecting cortical endpoints in older adults at risk of Alzheimer's disease

The paper examines associations between white matter microstructure and Aβ/tau pathology in specific brain bundles in at-risk older adults, finding diffusion metrics linked to Aβ and tau levels at cortical endpoints.

Functional brain age prediction suggests accelerated aging in preclinical familial Alzheimer's disease, irrespective of fibrillar amyloid-beta pathology

The paper develops a model to predict brain aging from resting state fMRI and finds accelerated brain aging in preclinical Alzheimer's disease, independent of amyloid-beta pathology.

Distinct changes in morphometric networks in aging versus Alzheimer’s disease dementia

The paper identifies distinct morphometric network changes in aging and Alzheimer’s disease, showing additive effects of aging and AD on GM loss, with unique whole-brain pattern variability in AD.

Subtypes of functional brain connectivity as early markers of neurodegeneration in Alzheimer’s disease

The paper identifies subtypes of functional brain connectivity in older adults linked to Alzheimer's disease symptoms and risk factors.