This study shows that MePD Ucn3 neurons suppress LH pulsatility via GABA and glutamate signaling and modulate HPA/HPG axes through projections to the PVN in female mice.

Endocrinology · Nov 29, 2022Peer-reviewedNeuroscience

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice

Geffen Lass, Xiao Feng Li, Margaritis Voliotis, Ellen Wall, Ross de Burgh, Deyana Ivanova, Caitlin McIntyre, Xian‐Hua Lin, William Henry Colledge, Stafford Louis Lightman, Krasimira T. Tsaneva-Atanasova, Kevin T. O'Byrne

The paper investigates how kisspeptin neurons in the medial amygdala modulate GnRH pulse frequency through GABA and glutamate neurotransmission in female mice.

Journal of Neuroendocrinology · Oct 17, 2022Peer-reviewedNeuroscience

Role of posterodorsal medial amygdala urocortin-3 in pubertal timing in female mice

Deyana Ivanova, Xiao-Feng Li, Yali Liu, Caitlin McIntyre, Cathy Fernandes, Geffen Lass, Lingsi Kong, Kevin T. O’Byrne

This study shows that psychosocial stress delays puberty and increases anxiety in female mice by affecting Urocortin3 neurons in the medial amygdala.

Frontiers in Endocrinology · May 17, 2022Peer-reviewedNeuroscience

Modulation of pulsatile GnRH dynamics across the ovarian cycle: the role of glutamatergic transmission in the arcuate kisspeptin network.

Margaritis Voliotis, Xiao Feng Li, Ross Alexander De Burgh, Geffen Lass, Deyana Ivanova, Caitlin McIntyre, Kevin T. O’Byrne, Krasimira T. Tsaneva-Atanasova

The paper investigates how glutamatergic transmission modulates GnRH pulsatility in the arcuate kisspeptin network across the estrous cycle using optogenetics and mathematical modeling.

eLife · Nov 17, 2021Peer-reviewedNeuroscience