Author

Alexander J. Rajic

University of California San DiegoORCID 0000-0002-0645-7736Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Christina J. SigurdsoniD· 2 shared Daniel Ojeda-JuáreziD· 2 shared Katrin Soldau· 2 shared Daniel B. McClatchyiD· 1 shared Dipannita SarkariD· 1 shared Donald P. PizzoiD· 1 shared Emily Richards· 1 shared Gail Funk· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Christina J. SigurdsonORCID

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2 papers

Recent·Most cited

Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease

Alexander J. Rajic, Daniel Ojeda-Juárez, Dipannita Sarkar, Paige Sumowski, Samantha Flores, Mahsa Pourhamzeh, Katrin Soldau, Donald P. Pizzo, Christina J. Sigurdson

This study shows that phosphatase reduction and receptor hyperphosphorylation occur early in prion disease and precede inflammation.

bioRxiv · Oct 16, 2026 · PreprintNeuroscience

PrPC-induced signaling in human neurons activates phospholipase Cγ1 and an Arc/Arg3.1 response

Daniel Ojeda-Juárez, Gail Funk, Emily Richards, Alexander J. Rajic, Daniel B. McClatchy, Katrin Soldau, Xu Chen, John R. Yates, Steven L. Gonias, Christina J. Sigurdson

The paper shows that PrPC ligands in human neurons trigger PLCγ1 signaling and an Arc/Arg3.1 response, indicating neuronal hyperactivity in prion disease.

bioRxiv · Apr 1, 2025 · PreprintNeuroscience