Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease
Alexander J. Rajic, Daniel Ojeda-Juárez, Dipannita Sarkar, Paige Sumowski, Samantha Flores, Mahsa Pourhamzeh, Katrin Soldau, Donald P. Pizzo, Christina J. Sigurdson
This study shows that phosphatase reduction and receptor hyperphosphorylation occur early in prion disease and precede inflammation.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience