Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model
Samantha Flores, Amanda Wilpitz, Daniel Ojeda-Juárez, Jin Wang, Garrett A Danque, Paige Sumowski, Gail Funk, Adela Malik, Donald P. Pizzo, Emily Richards, Jeffrey J. Iliff, Christina J. Sigurdson
This study shows that reducing AQP4 function in a prion-CAA mouse model prolongs survival and reduces neuroinflammation without affecting prion spread.
bioRxiv · Jul 17, 2026 · PreprintNeuroscience