Daniel Ojeda-Juárez

This study shows that phosphatase reduction and receptor hyperphosphorylation occur early in prion disease and precede inflammation.

This study shows that reducing AQP4 function in a prion-CAA mouse model prolongs survival and reduces neuroinflammation without affecting prion spread.

The paper shows that PrPC ligands in human neurons trigger PLCγ1 signaling and an Arc/Arg3.1 response, indicating neuronal hyperactivity in prion disease.