Author

Marlin D Figgins

Fred Hutch Cancer CenterORCID 0000-0002-0686-0816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

John HuddlestoniD· 2 shared Trevor BedfordiD· 2 shared Andrea N. LoesiD· 1 shared Caroline KikawaiD· 1 shared Elizabeth M. DrapeauiD· 1 shared Frederick A. Matsen IViD· 1 shared Heidi PeckiD· 1 shared Hugh K. HaddoxiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

John HuddlestonORCID

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2 papers

Recent·Most cited

antigen-prime: Simulating coupled genetic and antigenic evolution of influenza virus

Zorian Thornton, Thien Tran, Marlin D Figgins, John Huddleston, Trevor Bedford, Frederick A. Matsen IV, Hugh K. Haddox

The paper introduces a simulator called antigen-prime to model influenza virus evolution and benchmarks methods for variant assignment and growth rate estimation.

bioRxiv · Aug 21, 2026 · PreprintBioinformatics

High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

Caroline Kikawa, Andrea N. Loes, John Huddleston, Marlin D Figgins, Philippa L. Steinberg, Tachianna Griffiths, Elizabeth M. Drapeau, Heidi Peck, Ian Barr, Janet A. Englund, Scott E. Hensley, Trevor Bedford, Jesse D. Bloom

A sequencing-based neutralization assay across 78 H3N2 HA strains and 150 sera shows strain growth in 2023 tracks the fraction of sera with low titers, but not pooled-serum titers.

eLife · Feb 23, 2026Peer-reviewedEvolutionary Biology✦ In-depth digest