Elizabeth M. Drapeau

Strain-specific differences in the response to egg-derived versus recombinant protein influenza vaccines

This study compares neutralizing antibody titers from egg-derived and recombinant protein influenza vaccines against diverse H1N1 strains, finding that egg-derived vaccines induce less boost against a new clade with specific antigenic mutations.

Serial vaccination expands and refines human CD4+ T cell memory

This study tracks CD4+ T cell memory development after three mRNA vaccinations in SARS-CoV-2-naive individuals, showing primary vaccination drives memory pool size and boosters refine its quality and breadth.

Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk

The study assesses the pandemic risk of a fatal zoonotic H3N8 influenza virus from chickens, finding it has moderate pandemic potential due to its ability to infect humans and replicate in human cells.

High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

A sequencing-based neutralization assay across 78 H3N2 HA strains and 150 sera shows strain growth in 2023 tracks the fraction of sera with low titers, but not pooled-serum titers.

Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selection

Sequencing-based neutralization of 91 H3N2 and H1N1 hemagglutinins against 302 human sera (27,409 titers) shows reduced titers to H3N2 subclade K and H1N1 D.3.1.1.