Ulrich H. E. Hansmann

Modulating Transthyretin Fibril Stability with D-Retro-Inverso Peptides

The paper uses molecular dynamics simulations to study how D-Retro-Inverso peptides modulate TTR fibril stability and identifies DRI-K6V as a potential disruptor of TTR fibrils.

Early Steps in Pathogen-induced TTR-amyloid-formation

The paper uses molecular dynamics simulations to investigate if SARS-CoV-2 peptides can initiate TTR tetramer dissociation, leading to amyloidosis.

D-Retro-Inverso Peptide Candidates for Inhibiting SAA Cardiac Amyloidosis

The paper designs and evaluates D-amino acid-based peptides to inhibit SAA3 fibril formation in a mouse model of cardiac amyloidosis.

The Effect of SARS-COV-2 Protein Fragments onthe Dimerization of α-Synuclein

This study uses molecular dynamics simulations to show that SARS-COV-2 protein fragments alter α-synuclein dimer conformations, favoring rod-like fibrils over twister-like structures.

Modulation of Aβ1-42 Aggregation by a SARS-COV-2 Protein Fragment

The paper investigates how a SARS-CoV-2 Spike protein fragment interacts with Aβ1-42 monomers and fibrils using molecular dynamics simulations.

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

Interconversion between Serum Amyloid A native and fibril conformations

This study investigates the conformational interconversion between native and fibril forms of SAA1-76 using Replica-Exchange-with-Tunneling, finding low energy barriers and identifying a critical salt bridge for fibril formation.

D-Retro Inverso (DRI) Amylin and the Stability of Amylin Fibrils

This study compares the stability of regular amylin fibrils with DRI-amylin fibrils, finding differences in hydrogen bonding and fibril stability when interacting with regular amylin.