Author

Charlie W. Lees

National Health ServiceORCID 0000-0002-0732-8215Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ailsa L HartiD· 2 shared Aleksejs SazonovsiD· 2 shared Carl A. AndersoniD· 2 shared Christian P. SelingeriD· 2 shared Dermot P.B. McGoverniD· 2 shared Fraser J.R. CummingsiD· 2 shared Miles ParkesiD· 2 shared Nicholas Alexander KennedyiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Ailsa L HartORCID

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Author profile →

2 papers

Recent·Most cited

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

Ruifei Zhu, Qian Zhang, Kai Yuan, Rui Zhang, Alexandra K. Turvey, Christine R. Stevens, Laura Fachal, Tariq Ahmad, Klaartje Bel Kok, Charles Noah Bernstein, Bernd Bokemeyer, Steven R. Brant, Johanne Brooks, Jeffrey R. Butterworth, Judy H. Cho, , Carl A. Anderson

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

medRxiv · May 20, 2026 · PreprintGenetic & Genomic Medicine

HLA-DQA1*05 is associated with the development of antibodies to anti-TNF therapy

Aleksejs Sazonovs, Nicholas Alexander Kennedy, Loukas Moutsianas, Graham Heap, Daniel L Rice, Mark Reppell, Claire Bewshea, Neil Chanchlani, G Walker, Mandy H. Perry, Timothy James McDonald, Charlie W. Lees, Fraser J.R. Cummings, Miles Parkes, John C. Mansfield, , Thankam Paul

This study identifies HLA-DQA1*05 as a genetic risk factor for anti-drug antibody development in Crohn's disease patients treated with anti-TNF therapies.

Gastroenterology · Oct 7, 2019Peer-reviewedGenomics