Author

Jesper E. Dreier

University of CopenhagenORCID 0000-0002-0740-1750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Celine GalvagnioniD· 4 shared Alisdair StevensoniD· 3 shared Thomas C. T. MichaelsiD· 3 shared Katharina SchottiD· 2 shared Alexander J. DeariD· 1 shared Alexander Kai BuelliD· 1 shared Benjamin DehayiD· 1 shared David VoderholzeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiophysics

Celine GalvagnionORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Lipidic α-synuclein fibrils catalyze the formation of pathological mature fibrils

Alisdair Stevenson, Jesper E. Dreier, Nina Baumgartner, Natascha T. Christiansen, Celine Galvagnion, Thomas C. T. Michaels

This study shows lipidic α-synuclein fibrils catalyze the formation of mature fibrils through a heterogeneous nucleation mechanism, lowering the energy barrier and following Ostwald's Rule of Stages.

bioRxiv · Nov 5, 2026 · PreprintBiophysics

Shared and Distinct Lipid Profiles in amygdala from Sporadic and GBA-associated Parkinson's Diseases

Sonia Sanz Muñoz, Frederik Ravnkilde Marlet, Jesper E. Dreier, Mesut Bilgin, Katharina Schott, Krista B. S. Neergaard, Erwan Bézard, Benjamin Dehay, Zane Jaunmuktane, Kenji Maeda, Céline Galvagnion

This study identifies shared and distinct lipid profile changes in amygdala from sporadic and GBA-associated Parkinson's Disease, linking lipid metabolism to alpha-synuclein and glucocerebrosidase activity.

npj Parkinson s Disease · May 11, 2026Peer-reviewedNeuroscience

Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates

Jesper E. Dreier, Alisdair Stevenson, Elliot Carles, Katharina Schott, Thomas C. T. Michaels, Céline Galvagnion

This study shows Ambroxol inhibits α-synuclein-lipid coaggregation by displacing α-synuclein from membranes and preventing early coaggregate formation in GBA mutation models.

Chemical Science · Oct 31, 2025Peer-reviewedBiophysics

Global kinetic model of lipid-induced alpha-synuclein aggregation and its inhibition by small molecules

Alisdair Stevenson, Roxine Staats, Alexander J. Dear, David Voderholzer, Jesper E. Dreier, Georg Meisl, Raphael Guido, Tuomas P. J. Knowles, Céline Galvagnion, Alexander Kai Buell, Michele Vendruscolo, Thomas C. T. Michaels

This paper develops a global kinetic model of lipid-induced alpha-synuclein aggregation and identifies how squalamine inhibits this process by reducing lipid-dependent primary nucleation.

Proceedings of the National Academy of Sciences · Jun 25, 2025Peer-reviewedBiophysics