Uri Nimrod Ramírez-Jarquín

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain.

This study shows Rhes moves between neurons and transports mutant huntingtin in the brain, with Rhes deletion reducing this transport.

Deletion of Small Ubiquitin-like Modifier-1 Attenuates Behavioral and Anatomical Deficits by Enhancing Functional Autophagic Activities in Huntington Disease

This study shows that deleting SUMO1 in HD mice reduces motor and neurological impairments by enhancing autophagy and reducing mHTT levels.

The Mammalian Target of Rapamycin (mTOR) Kinase Mediates Haloperidol-Induced Cataleptic Behavior

This study shows that mTORC1 in the striatum prevents haloperidol-induced catalepsy, suggesting it could be a target for reducing antipsychotic side effects.

cGAS, a DNA Sensor, Promotes Inflammatory Responses in Huntington Disease

This study identifies cGAS as a key DNA sensor upregulated in Huntington disease, promoting inflammation and autophagy through increased mRNA occupancy and protein activity.

Rhes, a Striatal-Enriched Protein, Promotes Mitophagy Via Nix.

This study identifies Rhes as a striatal-enriched protein that promotes mitophagy via Nix, contributing to striatal vulnerability in the brain.

RasGRP1 (CalDAG-GEF-II) Mediates L-DOPA-induced Dyskinesia in a Mouse Model of Parkinson Disease

This study identifies RasGRP1 as a key mediator of L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease, showing its role in multiple signaling pathways and potential as a therapeutic target.