Manish Sharma

This study shows Rhes moves between neurons and transports mutant huntingtin in the brain, with Rhes deletion reducing this transport.

This study shows that deleting SUMO1 in HD mice reduces motor and neurological impairments by enhancing autophagy and reducing mHTT levels.

This study identifies cGAS as a key DNA sensor upregulated in Huntington disease, promoting inflammation and autophagy through increased mRNA occupancy and protein activity.

This study identifies Rhes as a striatal-enriched protein that promotes mitophagy via Nix, contributing to striatal vulnerability in the brain.

This study shows mutant huntingtin (mHtt) stalls ribosomes and suppresses protein synthesis independently of FMRP, using ribosome profiling in HD cells and mouse models.