Jan Claesen

Gut microbially produced phenolic acids have differential and sex-dependent effects on host metabolic health

The paper investigates the metabolic effects of phenolic acids produced by gut microbiota in a mouse model of diet-induced obesity, revealing sex-dependent impacts on glucose tolerance and lipid metabolism.

Mechanistic prediction of fecal microbiota transplant engraftment and Clostridioides difficile colonization resistance with μODE

This paper introduces muODE, a framework that simulates microbial community dynamics using metagenomics data to predict FMT outcomes and C. difficile resistance.

Oxidative stress induces E. coli aryl polyene expression, sensitizing the bacterial stress response and modulating the redox environment of innate immune cells

This study shows that oxidative stress induces APE expression in E. coli, enhancing bacterial growth and modulating host immune cell redox environments.

The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in ApcMin/+ mice

This study shows nisin Z reduces intestinal tumor burden in ApcMin/+ mice by modulating inflammation and the gut microbiome.

Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders

This study shows that dietary elderberry extract, through gut microbial conversion to hydrocinnamic acid, improves obesity-related metabolic disorders in mice by enhancing insulin sensitivity and reducing liver fat.