Author

Alison O’Neil

Wesleyan UniversityORCID 0000-0002-0759-4740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adithi Wijesekera· 1 shared Andres F. Salazar‐Chaparro· 1 shared Christian P. Schaaf· 1 shared Daniel Kulick· 1 shared Emilie J. KorchakiD· 1 shared Eric Zanderigo· 1 shared Hamza KhaniD· 1 shared Irina BezsonovaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Adithi Wijesekera

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Alzheimer's Disease Brain Organoids as a Source of Disease Relevant Amyloid-Beta Oligomers

Eric Zanderigo, Manaal Fatima, Sandy Becker, Alison O’Neil

This study uses AD-mutated brain organoids to generate disease-relevant Aβ oligomers for research and therapeutic development.

bioRxiv · Mar 12, 2026 · PreprintNeuroscience

Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons

Oliver Clackson, Muhammad Reza Hamid, Adithi Wijesekera, Daniel Kulick, Alison O’Neil

This study shows that cis-chlordane exposure causes mitochondrial dysfunction in motor neurons, resembling ALS features, and suggests its role in ALS pathogenesis.

PLoS ONE · Oct 14, 2025Peer-reviewedNeuroscience

Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation

Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro, Irina V. Semenova, Hamza Khan, Alison O’Neil, Pilar Caro, Christian P. Schaaf, Sara J. Buhrlage, Irina Bezsonova

This study analyzes 11 USP7 variants in Hao-Fountain syndrome, showing they affect enzyme activity, stability, and substrate recognition, with some variants responsive to an allosteric activator.

Proceedings of the National Academy of Sciences · Sep 22, 2025Peer-reviewedBiochemistry