Author

Irina V. Semenova

University of ConnecticutORCID 0000-0002-4435-3524Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Irina BezsonovaiD· 2 shared Alison O’NeiliD· 1 shared Andres F. Salazar‐Chaparro· 1 shared Bing HaoiD· 1 shared Christian P. Schaaf· 1 shared Dane H. Geddes-BuehreiD· 1 shared Daniel FairchildiD· 1 shared Emilie J. KorchakiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Irina BezsonovaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 20, 2026

PXL: a Nucleic Acid-Binding Module of Promyelocytic Leukemia Protein

Daniel Fairchild, Irina V. Semenova, Dane H. Geddes-Buehre…·Irina Bezsonova

This study identifies a novel nucleic acid-binding module, PXL, in PML-1 and shows it binds G-rich RNA/DNA and modulates the transcriptome.

DOI 10.64898/2026.02.19.706916

DNA methylationbulk RNA-seq

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 22, 2025

Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation

Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet…·Irina Bezsonova

This study analyzes 11 USP7 variants in Hao-Fountain syndrome, showing they affect enzyme activity, stability, and substrate recognition, with some variants responsive to an allosteric activator.

5 citations

humanproteomics

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