Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation
Jessica D. Daley, Elina Mukherjee, A. Carolina Tufino, Nathanael G. Bailey, Shanthi Bhaskar, Nivitha Periyapatna, Ian MacFawn, Sheryl R. Kunning, Cynthia S. Hinck, Tullia Carmela Bruno, Adam C. Olson, Linda M. McAllister‐Lucas, Andrew P. Hinck, Kristine L. Cooper, Riyue Bao, , Kelly M. Bailey
The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.
bioRxiv · May 7, 2024 · PreprintCancer Biology