Anthony Richard Cillo

SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance

The paper analyzes paired tumor biopsies from Ewing sarcoma patients before and after pembrolizumab therapy to identify features of resistance to checkpoint inhibition.

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

Immunocompetent murine model of Ewing sarcoma reveals role for TGFβ inhibition to enhance immune infiltrates in Ewing tumors during radiation

The paper develops an immunocompetent mouse model of Ewing sarcoma to show that TGFβ inhibition enhances immune infiltration and reduces metastasis during radiation therapy.

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

BAMM-SC: A Bayesian mixture model for clustering droplet-based single cell transcriptomic data from population studies

BAMM-SC clusters droplet-based scRNA-seq data from multiple individuals by accounting for batch effects and heterogeneity, improving accuracy over existing methods.