Nisi Jiang

The paper shows that castration at different ages in mice affects male mortality differently, with later castration providing greater survival benefits and suggesting age-dependent effects of testicular factors on longevity.

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

The paper reanalyzes ITP data using the Gehan test, identifying 5 compounds that extend mouse lifespan, missed by the log-rank test.