James F. Nelson

The paper shows that castration at different ages in mice affects male mortality differently, with later castration providing greater survival benefits and suggesting age-dependent effects of testicular factors on longevity.

The paper develops a prediction-interval framework to identify outlier control cohorts in lifespan studies using data from the National Institute on Aging Interventions Testing Program.

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

The paper reanalyzes ITP data using the Gehan test, identifying 5 compounds that extend mouse lifespan, missed by the log-rank test.