Randy Strong

The paper shows that castration at different ages in mice affects male mortality differently, with later castration providing greater survival benefits and suggesting age-dependent effects of testicular factors on longevity.

This study identifies genetic loci affecting lifespan dynamics, sex differences, and body weight trade-offs in mice using an actuarial approach.

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

This study examines primary osteoarthritis in aged UM-HET3 mice, finding sex-specific effects of MB and MitoQ treatments and correlations between cartilage scores and inflammation, cell cycle markers, and subchondral bone changes.

The paper reanalyzes ITP data using the Gehan test, identifying 5 compounds that extend mouse lifespan, missed by the log-rank test.

This study shows DOPAL promotes αSynuclein accumulation and impairs proteostasis in neuronal projections, contributing to Parkinson's disease progression.