Zeda Zhang

Functional interrogation uncovers a critical role for a high-plasticity cell state in lung adenocarcinoma

In vivo lineage tracing and targeted ablation in autochthonous mouse lung adenocarcinoma establish the Slc4a11+ high-plasticity cell state as a bidirectional transition hub driving tumor progression and therapy resistance.

Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer

This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.