Oligomerization-driven MLKL ubiquitylation antagonises necroptosis
Zikou Liu, Laura F. Dagley, Kristy Shield‐Artin, Samuel N. Young, Aleksandra Bankovacki, Xiangyi S. Wang, Michelle Tang, Jason A. Howitt, Che A. Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E. Garnish, Andrew Ian Webb, David Komander, James M. Murphy, , John Silke
This study demonstrates that MLKL ubiquitylation, triggered by oligomerization, regulates necroptosis by modulating MLKL activity and turnover.
bioRxiv · May 1, 2021 · PreprintMolecular Biology