Author

Kristy Shield‐Artin

The University of MelbourneORCID 0000-0002-3969-9846Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander DobroviciD· 2 shared Cassandra J. VandenbergiD· 2 shared Ksenija NesiciD· 2 shared Lijun XuiD· 2 shared A. Ferrier· 1 shared A. Glasgow· 1 shared A. Mellon· 1 shared Adam C. Martyn· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Alexander DobrovicORCID

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Author profile →

3 papers

Recent·Most cited

Generation of a PARPi-sensitive homozygous BRCA1-methylated OVCAR8 cell line using targeted CRISPR gene editing

Ksenija Nesic, Sally Beard, Lijun Xu, Olga Kondrashova, Cassandra J. Vandenberg, Alan F. Rubin, Fan Zhang, Alexander Dobrovic, Nicola Waddell, Clare L. Scott, Kristy Shield‐Artin, Matthew J. Wakefield

The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.

bioRxiv · Sep 23, 2024 · PreprintCancer Biology

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Qi Cai, Tanya Todorova Kwan, Elizabeth Lieschke, Gwo‐Yaw Ho, Holly E. Barker, Justin Bedő, Silvia Casadei, Andrew Farrell, Marc R. Radke, Kristy Shield‐Artin, , Lyndal S. Edwards

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Molecular Cancer · Aug 5, 2024Peer-reviewedGenetic & Genomic Medicine

Oligomerization-driven MLKL ubiquitylation antagonises necroptosis

Zikou Liu, Laura F. Dagley, Kristy Shield‐Artin, Samuel N. Young, Aleksandra Bankovacki, Xiangyi S. Wang, Michelle Tang, Jason A. Howitt, Che A. Stafford, Ueli Nachbur, Cheree Fitzgibbon, Sarah E. Garnish, Andrew Ian Webb, David Komander, James M. Murphy, , John Silke

This study demonstrates that MLKL ubiquitylation, triggered by oligomerization, regulates necroptosis by modulating MLKL activity and turnover.

bioRxiv · May 1, 2021 · PreprintMolecular Biology