Fabio Parisi

Locat identifies localized marker genes by testing both enrichment within and depletion outside cell populations in single-cell transcriptomics.

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

LMD identifies localized genes in single-cell RNA-seq data to characterize cellular diversity without batch correction, outperforming existing methods.

The paper develops a method to detect co-mutated pathways in cancer samples and identifies enriched pathway pairs across six cancer types, suggesting potential mechanisms for immune evasion.